Chlorodysinosin a
WebJul 1, 2008 · The first enantiocontrolled total synthesis of the marine sponge metabolite chlorodysinosin A is described, which is the most potent inhibitor of the serine proteases thrombin, factor VIIa, and factor Xa, which are critical enzymes in the process leading to platelet aggregation and fibrin mesh formation in humans. Expand
Chlorodysinosin a
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WebN-Acyloxyiminium ions generated from 4-substituted l-pyroglutamic esters with 4-(3-butenyl), 4-(3-butynyl), 4-(3-cinnamylmethyl), and 4-allenic tethers undergo rapid Lewis acid mediated carbocyclization to give stereodefined azacyclic compounds depending on the nature of the nucleophilic tether. In general, reactions of alkenes and alkynes with terminal alkyl or aryl … Webchon·dro·sin. A disaccharide composed of one molecule of d-glucuronic acid and one of d-galactosamine (chondrosamine); a component of the chondroitins.
WebTotal Synthesis and Structural Confirmation of Chlorodysinosin A more. by Niklas Blomberg. ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. WebOct 25, 2015 · Total Synthesis and Structural Confirmation of Chlorodysinosin A Stephen Hanessian, Juan R. Del Valle, Yafeng Xue, and Niklas Blomberg — 10491–10495 Electron Self-Exchange between Au140+/0 Nanoparticles Is Faster Than That between Au38+/0 in Solid-State, Mixed-Valent Films Jai-Pil Choi and Royce W. Murray — 10496–10502
WebWithin the aeruginosin family of natural products, chlorodysinosin A is the most potent inhibitor of the serine proteases thrombin, factor VIIa, and factor Xa, which are critical … WebSemantic Scholar extracted view of "Total synthesis of aeruginosin 298-A analogs containing ring oxygenated variants of 2-carboxy-6-hydroxyoctahydroindole" by Xiaoping Nie et al.
WebBased on X-ray crystallographic data of complexes of chlorodysinosin A with the enzyme thrombin, a series of analogs were synthesized varying the nature of the P(1), P(2), and P(3) pharmacophoric ...
WebSynthesis of Chlorodysinosin A. C 26 H 43 ClN 6 O 10 S. Principal investigator. Stephen Hanessian. Publication year. 2006. Synthesis type. Total. teachers profile updateWebchlorodysinosin A [9] are most noteworthy (Fig. 1). The simple replacement of the D-leucyl residue in dysinosin A [10] with a chloroleucyl residue brought about a dramatic improvement in the IC 50 values for thrombin inhibition. Until this discovery, oscillarin [11] was the most potent in vitro thrombin in-hibitor (Fig. 1). teachers profile update linkWebChlorodysinosin A C26H43ClN6O10S CID 16079152 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … teachers profile sampleWebMay 24, 2024 · Hello, I Really need some help. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. I pretty … teachers profile formatWebJul 21, 2006 · Within the aeruginosin family of natural products, chlorodysinosin A is the most potent inhibitor of the serine proteases thrombin, factor VIIa, and factor Xa, which … teachers profile update odishaWebsilodosin Rapaflo Pharmacologic class: Alpha1-adrenergic receptor antagonist Therapeutic class: Benign prostatic hyperplasia (BPH) agent Pregnancy risk category B Action … teachersprogram.orgWebAug 22, 2006 · Request PDF On Aug 22, 2006, Stephen Hanessian and others published Total Synthesis and Structural Confirmation of Chlorodysinosin A [J. Am. Chem. Soc. 2006, 128, 10491−10495]. Find, read ... teachers profile updates