Webb11 apr. 2024 · RecA family recombinases are the core enzymes in the process of homologous recombination, and their normal operation ensures the stability of the genome and the healthy development of organisms. The UvsX protein from bacteriophage T4 is a member of the RecA family recombinases and plays a central role in T4 phage DNA … WebbThe route to engineering stability of a protein of interest lies largely with the available data. Where high-resolution structural data is available, rational design, based on fundamental …
Suppression of USP7 negatively regulates the stability of ETS …
WebbUSP9X regulates the protein stability and function of ETS1 and the E-twenty-six related gene (EGR), whereas USP22 deubiquitinates PU.1 and regulates myeloid differentiation … trophy ridge archery
Principles of Protein Stability and Their Application in …
Webb1) A known X-ray structure, or structure of homologue with at least 50% sequence identity, and access to a number (>25 with more than 30% sequence identity) of protein sequences from different species. 2) An assay to compare the functional activity of the PROSS-designed mutants relative to wild-type. WebbFör 1 dag sedan · The effect of temperature on the micellar properties of the alkylglucoside surfactant n-octyl-β-D-thioglucopyranoside (OTG) used for membrane protein solubilization has been investigated. Critical micelle concentration (CMC), apparent (φV) and partial (V¯M) molar volume changes of the studied surfactant, as well as thermodynamic … WebbComputational protein design. Weizmann Institute of Science. Apr 2014 - Jul 20245 years 4 months. During my Ph.D. at Prof. Sarel Fleishman's team, I developed a computational method for redesigning natural proteins for improved expression levels and stability in one-shot. The method, called PROSS, was applied to several 'tough-nut' proteins and ... trophy ridge bow sight battery