WebSep 13, 2024 · The first proof-of-concept study that laid a foundation for today’s PROTACs was conducted in 2001 [].This study showed that methionine aminopeptidase-2 (MetAp-2) can be bound to the SCFb-TRCP E3 ligase, ubiquitinated, and degraded. WebOct 6, 2024 · β-transducin repeat-containing protein (β-TrCP), one of the well-characterized F-box proteins, acts as a substrate receptor and constitutes an active SCF β-TrCP E3 ligase with a scaffold protein CUL1, a RING protein RBX1, and an adaptor protein SKP1. β-TrCP plays a critical role in the regulation of various physiological and pathological processes, …
SANTA CRUZ BIOTECHNOLOGY, INC. FBL5 (G-11): sc-390102
WebThe South Carolina Regional Transmission Planning (SCRTP) process was established by Dominion Energy South Carolina (Dominion Energy) and the South Carolina Public Service … WebMar 6, 2024 · Mechanically, SLC7A11-AS1 is co-localized with β-TRCP1 in the nucleus. The exon 3 of SLC7A11-AS1 interacts with the F-box motif of β-TRCP1, the critical domain that … bryce harper charging the mound
Ubiquitin-Dependent Regulation of Stem Cell Biology
WebmTOR promotes IRS-1 degradation through SCFb-TRCP E3 ubiquitin ligase. iScience 5, 1–18 5. Ding, M. et al. (2016) Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signal-ling. Nat. Cell Biol. 18, 319–327 6. Kennedy, B.K. and Lamming, D.W. (2016) The mechanis-tic target of rapamycin: the grand conducTOR of metabo-lism ... WebSCFB-TRCP-dependent manner. Specifically, E1 first transfers a ubiquitin residue to the E2 component (a UBE2D protein), and the UBE2D protein then associates with an E3 ubiquitin-protein ligase, which immediately transfers that residue to a protein that is targeted for degradation. In this fashion, the WebJun 1, 2000 · A motif similar to the IKK consensus phosphorylation site and recognition site for p-TRCP is present within residues 918-934 in the NFkBI p i05 C-terminus. p-TRCP can … excel between the sheets