WebJul 1, 2024 · The basic helix-loop-helix (bHLH) transcription factor family is one of the largest transcription factor gene families in Arabidopsis thaliana, and contains a bHLH motif that is highly conserved throughout eukaryotic organisms. Members of this family have two conserved motifs, a basic DNA binding region and a helix-loop-helix (HLH) region. These … WebThe basic Helix-Loop-Helix (bHLH) proteins are transcription factors that play important roles during the development of various metazoans including fly, nematode, and …

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt …

WebJul 1, 2010 · A phylogenetic analysis of the basic helix-loop-helix (bHLH) gene superfamily was performed using seven different species (human, mouse, rat, worm, fly, yeast, and plant Arabidopsis) and involving over 600 bHLH genes (Stevens et al., 2008).All bHLH genes were identified in the genomes of the various species, including expressed sequence tags, and … WebJun 6, 1995 · We show that both HIF-1 subunits are basic-helix-loop-helix proteins containing a PAS domain, defined by its presence in the Drosophila Per and Sim proteins and in the mammalian ARNT and AHR proteins. HIF-1 alpha is most closely related to Sim. HIF-1 beta is a series of ARNT gene products, which can thus heterodimerize with either HIF-1 … car emoji ios

Basic Helix Loop Helix Transcription Factor - an overview ...

WebMar 27, 2024 · Here we report that deletion of the SRC-3 basic helix-loop-helix (bHLH) domain blocks its proteasome-dependent turnover. We further identified two residues … WebMay 13, 1997 · Helix-loop-helix proteins are characterized by common possession of highly conserved bipartite domains for DNA binding and protein–protein interaction (1–2).A motif of mainly basic residues … A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate … See more The motif is characterized by two α-helices connected by a loop. In general, transcription factors (including this type) are dimeric, each with one helix containing basic amino acid residues that facilitate DNA binding. … See more A phylogenetic analysis suggested that bHLH proteins fall into 6 major groups, indicated by letters A through F. Examples of transcription factors containing a bHLH include: Group A • See more AHR; AHRR; ARNT; ARNT2; ARNTL; ARNTL2; ASCL1; ASCL2; ASCL3; ASCL4; ATOH1; ATOH7; ATOH8; BHLHB2; BHLHB3; BHLHB4; BHLHB5; See more • PDOC00038 in PROSITE • Basic+Helix-Loop-Helix+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more Since many bHLH transcription factors are heterodimeric, their activity is often highly regulated by the dimerization of the subunits. One subunit's expression or availability is often … See more • 1989: Murre et al. showed that dimers of various bHLH proteins bind to a short DNA motif (later called E-Box). This E-box consists of the See more • Basic helix-loop-helix leucine zipper transcription factors See more car emoji facebook