Web1 Jul 2014 · Chemical screens in the zebrafish were pioneered initially to identify compounds that could alleviate a mutant phenotype, ... response to APAP across species was a great advantage to then exploit the unique opportunity to perform an unbiased chemical screen in zebrafish that revealed a compound that could be directly used in … Webunbiased chemical screen in two lung adenocarcinoma cell lines, A549 and NCI-H1734, both of which harbor oncogenic KRAS mutations and truncating STK11 mutations, and which are TP53 wild type and mutant (R273L), respectively. We screened 1,924 compounds from the Molecular Libraries Small-Molecule Repository validation set (Supplementary
Uncovering the uncharacterized and unexpected: Unbiased …
Web11 Nov 2024 · Cilia are organelles for cellular signaling and motility. They are assembled in G0/G1 and disassembled prior to mitosis. Compared to what is known about ciliary assembly, less is understood about ciliary disassembly. To uncover new mechanisms of ciliary disassembly, we performed an unbiased chemical screen. Web9 Feb 2024 · Unbiased, hypothesis-free screens for modifiers of αSyn toxicity are a possibility to identify such new ways to counteract the pathological process in neurodegenerative synucleinopathies. Modifier screens for αSyn can be roughly divided into two categories: genetic modifier screens and compound modifier screens. bobby vinton fan club
Unbiased Forward Genetic Screening with Chemical …
Web25 Aug 2014 · It was an unbiased chemical screen, set up with no assumptions about what they might find. Especially in the era before the discovery of RNA interference and its usefulness in silencing genes, scientists needed chemical tools that would perturb biological processes in other ways, so they could understand in detail how the mechanisms they … WebHere, we highlight the few small-scale unbiased screens (Hoopfer et al., 2015; Davis et al., ... Chemical Mutagenesis Screen for Aggression. The original method to induce random mutations in the genome in most early screens including … WebUnbiased chemical screens have found that autophagy drugs are selective for aneuploid cells [Citation 12], suggesting autophagy drugs can exploit a CNA-driven therapeutic window. Further exacerbating aneuploidy in SOC is the near … bobby vinton earth angel